USP11 promotes glycolysis by regulating HIF-1α stability in hepatocellular carcinoma.

ABSTRACT: Understanding the mechanisms underlying metastasis in hepatocellular carcinoma (HCC) is crucial for developing new therapies against this fatal disease. Deubiquitinase ubiquitin-specific protease 11 (USP11) belongs to the deubiquitinating family and has previously been reported to play a critical role in cancer pathogenesis. Although it has been established that USP11 can facilitate the metastasis and proliferation ability of HCC, the underlying regulatory mechanisms are poorly understood. The primary objective of this research was to reveal hitherto undocumented functions of USP11 during HCC progression, especially those related to metabolism. Under hypoxic conditions, USP11 was found to significantly impact the glycolysis of HCC cells, as demonstrated through various techniques, includin

SUBMITTER: Qiao L 

PROVIDER: S-EPMC10826445 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature