Non-indicated initiation of proton pump inhibitor and risk of adverse outcomes in patients with underlying chronic kidney disease: a nationwide, retrospective, cohort study.

ABSTRACT:

Objective

Evidence related to the risk of kidney damage by proton pump inhibitor (PPI) initiation in patients with 'underlying' chronic kidney disease (CKD) remains scarce, although PPI use is generally associated with acute interstitial nephritis or incident CKD. We aimed to investigate the association between PPI initiation and the risk of adverse outcomes in patients with CKD in the absence of any deterministic indications for PPI usage.

Design

Retrospective observational study.

Setting

Korea National Health Insurance Service database from 2009 to 2017.

Participants

A retrospective cohort of new PPI and histamine H₂-receptor antagonists (H2RA) users among people with CKD. Patients with a history of gastrointestinal bleeding or those who had an end

SUBMITTER: Kim SG 

PROVIDER: S-EPMC10826563 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature