Transcription factor FOXP4 inversely governs tumor suppressor genes and contributes to thyroid cancer progression.

ABSTRACT:

Objective

In recent decades, thyroid cancer (TC) has exhibited a rising incidence pattern. Elevated levels of the transcription factor FOXP4 have been strongly linked to the progression of diverse tumors; nevertheless, its specific role in thyroid cancer remains underexplored. The primary objective of this study was to elucidate the functions of FOXP4 and its associated target gene, FBXW7, in the context of thyroid cancer.

Methods

FOXP4 and FBXW7 expression levels in TC tissues and cell lines were assessed through immunohistochemistry and RT-qPCR analyses. The functional aspects of FOXP4, including its effects on cell proliferation, migration capabilities, cell cycle regulation, and epithelial-mesenchymal transition (EMT), were investigated. Furthermore, the interaction betw

SUBMITTER: Zhou T 

PROVIDER: S-EPMC10826616 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature