Segmenting hypothalamic subunits in human newborn magnetic resonance imaging data.

ABSTRACT: Preclinical evidence suggests that inter-individual variation in the structure of the hypothalamus at birth is associated with variation in the intrauterine environment, with downstream implications for future disease susceptibility. However, scientific advancement in humans is limited by a lack of validated methods for the automatic segmentation of the newborn hypothalamus. N = 215 healthy full-term infants with paired T1-/T2-weighted MR images across four sites were considered for primary analyses (mean postmenstrual age = 44.3 ± 3.5 weeks, n_male /n_female  = 110/106). The outputs of FreeSurfer's hypothalamic subunit segmentation tools designed for adults (segFS) were compared against those of a novel registration-based pipeline developed here (segATLAS) and against

SUBMITTER: Rasmussen JM 

PROVIDER: S-EPMC10826633 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature