Ceramides improve cardiovascular risk prediction beyond low-density lipoprotein cholesterol.

ABSTRACT:

Aims

Low-density lipoprotein cholesterol (LDL-C) is the best documented cardiovascular risk predictor and at the same time serves as a target for lipid-lowering therapy. However, the power of LDL-C to predict risk is biased by advanced age, comorbidities, and medical treatment, all known to impact cholesterol levels. Consequently, such biased patient cohorts often feature a U-shaped or inverse association between LDL-C and cardiovascular or overall mortality. It is not clear whether these constraints for risk prediction may likewise apply to other lipid risk markers in particular to ceramides and phosphatidylcholines.

Methods and results

In this observational cohort study, we recorded cardiovascular mortality in 1195 patients over a period of up to 16 years, comprising a tot

SUBMITTER: Leiherer A 

PROVIDER: S-EPMC10826640 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature