Utility of metagenomic Next-Generation Sequencing for simultaneously detecting pathogens and neoplasms.

ABSTRACT:

Objectives

Clinicians often face the challenge of differentially diagnosing febrile patients who are suspected of infectious diseases, since the clinical manifestations of infection and cancer may overlap. A single test that can detect both pathogens and tumor could provide timely and accurate diagnostic clues to aid the treatment and management of these patients.

Methods

We enrolled eight patients to evaluate the utility of metagenomic Next-Generation Sequencing for simultaneously detecting pathogens and neoplasms using body fluids and tissue samples. Patients were selected by the following criteria: 1) Tumor was not considered upon hospitalization, but mNGS testing indicated neoplasm; 2) Tumor was not excluded, but microbial infection was primarily suspected according to i

SUBMITTER: Qin F 

PROVIDER: S-EPMC10826719 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature