Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil.

ABSTRACT: We generated 238 Zika virus (ZIKV) genomes from 135 persons in Brazil who had samples collected over 1 year to evaluate virus persistence. Phylogenetic inference clustered the genomes together with previously reported ZIKV strains from northern Brazil, showing that ZIKV has been remained relatively stable over time. Temporal phylogenetic analysis revealed limited within-host diversity among most ZIKV-persistent infected associated samples. However, we detected unusual virus temporal diversity from >5 persons, uncovering the existence of divergent genomes within the same patient. All those patients showed an increase in neutralizing antibody levels, followed by a decline at the convalescent phase of ZIKV infection. Of interest, in 3 of those patients, titers of neutralizing antibodies incre

SUBMITTER: da Costa Castilho M 

PROVIDER: S-EPMC10826783 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature