The gut-liver axis in cholangiopathies: focus on bile acid based pharmacological treatment.

ABSTRACT:

Purpose of review

This review analyses the main features of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) and provides an overview of the currently available (bile acid) bile acid related treatments.

Recent findings

In PBC, biliary injury is the consequence of a dysregulated intrahepatic and systemic immune response. Given the close association between PSC and inflammatory bowel disease (IBD), the microbiota represents an important factor in the development of PSC. Bile acid based pharmacological treatments could represent promising therapeutic strategies in the management of cholangiopathies.

Summary

Cholangiopathies include a spectrum of diseases resulting in cholestasis, an impairment of bile flow in the biliary tree, leading to biliary o

SUBMITTER: Cariello M 

PROVIDER: S-EPMC10826921 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature