Repurposing iron chelators for accurate positron emission tomography imaging tracking of radiometal-labeled cell transplants.

ABSTRACT: The use of radiolabeled cells for positron emission tomography (PET) imaging tracking has been a promising approach for monitoring cell-based therapies. However, the presence of free radionuclides released from dead cells during tracking can interfere with the signal from living cells, leading to inaccurate results. In this study, the effectiveness of the iron chelators deferoxamine (DFO) and deferiprone in removing free radionuclides ⁸⁹Zr and ⁶⁸Ga, respectively, was demonstrated in vivo utilizing PET imaging. The use of DFO during PET imaging tracking of ⁸⁹Zr-labeled mesenchymal stem cells (MSCs) significantly reduced uptake in bone while preserving uptake in major organs, resulting in more accurate and reliable tracking. Furthermore, the clearance of free

SUBMITTER: Xu Q 

PROVIDER: S-EPMC10827001 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature