Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition.

ABSTRACT: Gliomas are highly aggressive brain tumors characterized by poor prognosis and composed of diffusely infiltrating tumor cells that intermingle with non-neoplastic cells in the tumor microenvironment, including neurons. Neurons are increasingly appreciated as important reactive components of the glioma microenvironment, due to their role in causing hallmark glioma symptoms, such as cognitive deficits and seizures, as well as their potential ability to drive glioma progression. Separately, mTOR signaling has been shown to have pleiotropic effects in the brain tumor microenvironment, including regulation of neuronal hyperexcitability. However, the local cellular-level effects of mTOR inhibition on glioma-induced neuronal alterations are not well understood. Here we employed neuron-specific pr

SUBMITTER: Goldberg AR 

PROVIDER: S-EPMC10827113 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature