Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome.

ABSTRACT: Retroviruses exploit a variety of host proteins to assemble and release virions from infected cells. To date, most studies that examined possible interacting partners of retroviral Gag proteins focused on host proteins that localize primarily to the cytoplasm or plasma membrane. Given the recent findings that several full-length Gag proteins localize to the nucleus, identifying the Gag-nuclear interactome has high potential for novel findings that reveal previously unknown host processes. In this study, we systematically compared nuclear factors identified in published HIV-1 proteomic studies which had used a variety of experimental approaches. In addition, to contribute to this body of knowledge, we report results from a mass spectrometry approach using affinity-tagged (His₆) H

SUBMITTER: Lambert GS 

PROVIDER: S-EPMC10827203 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature