Mechanisms of gas sensing by internal sensory neurons in Drosophila larvae.

ABSTRACT: Internal sensory neurons monitor the chemical and physical state of the body, providing critical information to the central nervous system for maintaining homeostasis and survival. A population of larval Drosophila sensory neurons, tracheal dendrite (td) neurons, elaborate dendrites along respiratory organs and may serve as a model for elucidating the cellular and molecular basis of chemosensation by internal neurons. We find that td neurons respond to decreases in O₂ levels and increases in CO₂ levels. We assessed the roles of atypical soluble guanylyl cyclases (Gycs) and a gustatory receptor (Gr) in mediating these responses. We found that Gyc88E/Gyc89Db were necessary for responses to hypoxia, and that Gr28b was necessary for responses to CO₂. Tar

SUBMITTER: Lu S 

PROVIDER: S-EPMC10827222 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature