A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.

ABSTRACT: Personality is influenced by both genetic and environmental factors and is associated with other psychiatric traits such as anxiety and depression. The "Big Five" personality traits, which include neuroticism, extraversion, agreeableness, conscientiousness, and openness, are a widely accepted and influential framework for understanding and describing human personality. Of the big five personality traits, neuroticism has most often been the focus of genetic studies and is linked to various mental illnesses including depression, anxiety, and schizophrenia. Our knowledge of the genetic architecture of the other four personality traits is more limited. Utilizing the Million Veteran Program (MVP) cohort we conducted a genome-wide association study (GWAS) in individuals of European and African a

SUBMITTER: Gupta P 

PROVIDER: S-EPMC10827244 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature