Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.

ABSTRACT: Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in understanding the extent to which these relationships are causal, and to what extent shared genetic factors play a role. We explored the relationships between schizophrenia (Scz), cannabis use disorder (CanUD), and ever-regular tobacco smoking (Smk) using the largest available genome-wide studies of these phenotypes in individuals of African and European ancestries. All three phenotypes were positively genetically correlated (r_gs = 0.17 - 0.62). Causal inference analyses suggested the presence of horizontal pleiotropy, but evidence for bidirectional causal relationships was also found between all thre

SUBMITTER: Johnson EC 

PROVIDER: S-EPMC10827265 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature