Branched-chain amino acids and type 2 diabetes: a bidirectional Mendelian randomization analysis.

ABSTRACT:

Objective

Genetic studies have suggested that the branched-chain amino acids (BCAAs) valine, leucine, and isoleucine have a causal association with type 2 diabetes (T2D). However, inferences are based on a limited number of genetic loci associated with BCAAs.

Methods

Instrumental variables (IVs) for each BCAA were constructed and validated using large well-powered data sets and their association with T2D was tested using a two-sample inverse-variance weighted Mendelian randomization approach. Sensitivity analyses were performed to ensure the accuracy of the findings. A reverse association was assessed using instrumental variables for T2D.

Results

Estimated effect sizes between BCAA IVs and T2D, excluding outliers, were as follows: valine (β = 0.14 change in log-odds p

SUBMITTER: Mosley JD 

PROVIDER: S-EPMC10827349 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature