Type I interferon activates MHC class I-dressed CD11b⁺ conventional dendritic cells to promote protective anti-tumor CD8⁺ T cell immunity.

ABSTRACT: Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor immunity. To delineate the DC states associated with productive anti-tumor T cell immunity, we compared spontaneously regressing and progressing tumors. Tumor-reactive CD8⁺ T cell responses in Batf3^-/- mice lacking type 1 DCs (DC1s) were lost in progressor tumors but preserved in regressor tumors. Transcriptional profiling of intra-tumoral DCs within regressor tumors revealed an activation state of CD11b⁺ conventional DCs (DC2s) characterized by expression of interferon (IFN)-stimulated genes (ISGs) (ISG⁺ DCs). ISG⁺ DC-activated CD8⁺ T cells ex vivo comparably to DC1. Unlike cross-presenting DC1, ISG⁺ DCs acquired and p

SUBMITTER: Duong E 

PROVIDER: S-EPMC10827482 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature