Long-term major adverse liver outcomes in 1,260 patients with non-cirrhotic NAFLD.

ABSTRACT:

Background & aims

Long-term studies of the prognosis of NAFLD are scarce. Here, we investigated the risk of major adverse liver outcomes (MALO) in a large cohort of patients with NAFLD.

Methods

We conducted a cohort study with data from Swedish university hospitals. Patients (n = 1,260) with NAFLD without cirrhosis were diagnosed through biopsy or radiology, and had fibrosis estimated through vibration-controlled transient elastography, biopsy, or FIB-4 score between 1974 and 2020 and followed up through 2020. Each patient was matched on age, sex, and municipality with up to 10 reference individuals from the general population (n = 12,529). MALO were ascertained from Swedish national registers. The rate of events was estimated by Cox regression.

Results

MALO occurred

SUBMITTER: Akbari C 

PROVIDER: S-EPMC10827505 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature