Treatment Patterns of Cancer-associated Thrombosis in the Netherlands: The Four Cities Study.

ABSTRACT: Background  Current guidelines recommend either low-molecular weight heparin (LMWH) or direct oral anticoagulants (DOACs) as first-line treatment in cancer-associated venous thromboembolism (VTE). Aim  This study aimed to investigate treatment regimens for cancer-associated VTE over the past 5 years, explore predictors for initial treatment (LMWH vs. DOAC), and to assess the risks of recurrent VTE and bleeding. Methods  This was a Dutch, multicenter, retrospective cohort study including consecutive patients with cancer-associated VTE between 2017 and 2021. Treatment predictors were assessed with multivariable logistic regression models. Six-month cumulative incidences for recurrent VTE and major bleeding (MB) were estimated with death as competing risk. Results

SUBMITTER: Kaptein FHJ 

PROVIDER: S-EPMC10827569 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature