Statins and risks of dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong.

ABSTRACT:

Background

Heart failure (HF) and dementia frequently co-exist with shared pathological mechanisms and risk factors. Our study aims to investigate the association between statin therapy and the risks of dementia and its subtypes among patients with HF.

Methods

The Hong Kong Clinical Data Analysis and Reporting System database was interrogated to identify patients with incident HF diagnosis from 2004 to 2018, using ICD 9/ICD 10 codes. Inverse probability of treatment weighting (IPTW) was used to balance baseline covariates between statin users (N = 54,004) and non-users (N = 50,291). The primary outcomes were incident all-cause dementia, including subtypes of Alzheimer's disease, vascular dementia, and unspecified dementia. Cox proportional-hazard model with competing risk re

SUBMITTER: Ren QW 

PROVIDER: S-EPMC10827582 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature