O-GlcNAc transferase acts as a critical nutritional node for the control of liver homeostasis.

ABSTRACT:

Background & aims

O-GlcNAcylation is a reversible post-translational modification controlled by the activity of two enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). In the liver, O-GlcNAcylation has emerged as an important regulatory mechanism underlying normal liver physiology and metabolic disease.

Methods

To address whether OGT acts as a critical hepatic nutritional node, mice with a constitutive hepatocyte-specific deletion of OGT (OGT^LKO) were generated and challenged with different carbohydrate- and lipid-containing diets.

Results

Analyses of 4-week-old OGT^LKO mice revealed significant oxidative and endoplasmic reticulum stress, and DNA damage, together with inflammation and fibrosis, in the liver. Susc

SUBMITTER: Ortega-Prieto P 

PROVIDER: S-EPMC10827605 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature