Trans-ancestry meta-analysis of genome wide association studies of inhibitory control.

ABSTRACT: Deficits in effective executive function, including inhibitory control are associated with risk for a number of psychiatric disorders and significantly impact everyday functioning. These complex traits have been proposed to serve as endophenotypes, however, their genetic architecture is not yet well understood. To identify the common genetic variation associated with inhibitory control in the general population we performed the first trans-ancestry genome wide association study (GWAS) combining data across 8 sites and four ancestries (N = 14,877) using cognitive traits derived from the stop-signal task, namely - go reaction time (GoRT), go reaction time variability (GoRT SD) and stop signal reaction time (SSRT). Although we did not identify genome wide significant associations for any of t

SUBMITTER: Arnatkeviciute A 

PROVIDER: S-EPMC10827666 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature