Influence of copper(I) nicotinate complex on the Notch1 signaling pathway in triple negative breast cancer cell lines.

ABSTRACT: Triple negative breast cancer (TNBC) is a subtype of breast cancer which is characterized by its aggressiveness, poor and short overall survival. In this concept, there is a growing demand for metal-based compounds in TNBC therapy as copper complex that have a less toxic effect on normal cells and could stimulate apoptotic cell death. Additionally, Notch1 signaling pathway has received great attention as one of the most important potential targets for developing a novel therapeutic strategy. The present study is an attempt to assess the promising chemotherapeutic activities of copper(I) nicotinate (CNC) through its impact on the expression of downstream genes of Notch1 signaling pathway and the cell fate of TNBC. The co-treatment of TNBC cells with doxorubicin (Doxo) and CNC was also inves

SUBMITTER: Abdel-Mohsen MA 

PROVIDER: S-EPMC10827744 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature