Assessment of Brain Tumour Perfusion Using Early-Phase ¹⁸F-FET PET: Comparison with Perfusion-Weighted MRI.

ABSTRACT:

Purpose

Morphological imaging using MRI is essential for brain tumour diagnostics. Dynamic susceptibility contrast (DSC) perfusion-weighted MRI (PWI), as well as amino acid PET, may provide additional information in ambiguous cases. Since PWI is often unavailable in patients referred for amino acid PET, we explored whether maps of relative cerebral blood volume (rCBV) in brain tumours can be extracted from the early phase of PET using O-(2-¹⁸F-fluoroethyl)-L-tyrosine (¹⁸F-FET).

Procedure

Using a hybrid brain PET/MRI scanner, PWI and dynamic ¹⁸F-FET PET were performed in 33 patients with cerebral glioma and four patients with highly vascularized meningioma. The time interval from 0 to 2 min p.i. was selected to best reflect the blood pool phas

SUBMITTER: Filss CP 

PROVIDER: S-EPMC10827807 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature