Intrinsic brain functional connectivity predicts treatment-related motor complications in early Parkinson's disease patients.

ABSTRACT:

Background

Treatment-related motor complications may develop progressively over the course of Parkinson's disease (PD).

Objective

We investigated intrinsic brain networks functional connectivity (FC) at baseline in a cohort of early PD patients which successively developed treatment-related motor complications over 4 years.

Methods

Baseline MRI images of 88 drug-naïve PD patients and 20 healthy controls were analyzed. After the baseline assessments, all PD patients were prescribed with dopaminergic treatment and yearly clinically re-assessed. At the 4-year follow-up, 36 patients have developed treatment-related motor complications (PD-Compl) whereas 52 had not (PD-no-Compl). Single-subject and group-level independent component analyses were used to investigate FC chan

SUBMITTER: De Micco R 

PROVIDER: S-EPMC10827831 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature