Childhood development of brain white matter myelin: a longitudinal T1w/T2w-ratio study.

ABSTRACT: Myelination of human brain white matter (WM) continues into adulthood following birth, facilitating connection within and between brain networks. In vivo MRI studies using diffusion weighted imaging (DWI) suggest microstructural properties of brain WM increase over childhood and adolescence. Although DWI metrics, such as fractional anisotropy (FA), could reflect axonal myelination, they are not specific to myelin and could also represent other elements of WM microstructure, for example, fibre architecture, axon diameter and cell swelling. Little work exists specifically examining myelin development. The T1w/T2w ratio approach offers an alternative non-invasive method of estimating brain myelin. The approach uses MRI scans that are routinely part of clinical imaging and only require short a

SUBMITTER: Dipnall LM 

PROVIDER: S-EPMC10827845 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature