The CXCL16-CXCR6 axis in glioblastoma modulates T-cell activity in a spatiotemporal context.

ABSTRACT:

Introduction

Glioblastoma multiforme (GBM) pathobiology is characterized by its significant induction of immunosuppression within the tumor microenvironment, predominantly mediated by immunosuppressive tumor-associated myeloid cells (TAMCs). Myeloid cells play a pivotal role in shaping the GBM microenvironment and influencing immune responses, with direct interactions with effector immune cells critically impacting these processes.

Methods

Our study investigates the role of the CXCR6/CXCL16 axis in T-cell myeloid interactions within GBM tissues. We examined the surface expression of CXCL16, revealing its limitation to TAMCs, while microglia release CXCL16 as a cytokine. The study explores how these distinct expression patterns affect T-cell engagement, focusing on the conseq

SUBMITTER: Chia TY 

PROVIDER: S-EPMC10827847 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature