Causal effects from inflammatory bowel disease on liver function and disease: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Accumulating evidence has shown that patients with inflammatory bowel disease (IBD) have liver function abnormalities and are susceptible to liver diseases. However, the existence of a causal relationship between IBD and liver function or disease remains unclear.

Methods

A two-sample Mendelian randomization (MR) analysis was performed using genetic associations from publicly available genome-wide association studies (GWAS). These associations encompass ulcerative colitis (UC), Crohn's disease (CD), liver function traits, and liver disease phenotypes. The liver function traits comprised hepatic biochemistries, percent liver fat, and liver iron content from the UK Biobank. Furthermore, the liver disease phenotypes included cholelithiasis, non-alcoholic fatty liver d

SUBMITTER: Shu Y 

PROVIDER: S-EPMC10827874 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature