Different cortical connectivities in human females and males relate to differences in strength and body composition, reward and emotional systems, and memory.

ABSTRACT: Sex differences in human brain structure and function are important, partly because they are likely to be relevant to the male-female differences in behavior and in mental health. To analyse sex differences in cortical function, functional connectivity was measured in 36,531 participants (53% female) in the UK Biobank (mean age 69) using the Human Connectome Project multimodal parcellation atlas with 360 well-specified cortical regions. Most of the functional connectivities were lower in females (Bonferroni corrected), with the mean Cohen's d =  - 0.18. Removing these as covariates reduced the difference of functional connectivities for females-males from d =  - 0.18 to - 0.06. The lower functional connectivities in females were especially of somatosensory/premotor regions including the in

SUBMITTER: Zhang R 

PROVIDER: S-EPMC10827883 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature