The value of routine blood work-up in clinical stratification and prognosis of patients with amyotrophic lateral sclerosis.

ABSTRACT:

Background

There is an unmet need in amyotrophic lateral sclerosis (ALS) to provide specific biomarkers for the disease. Due to their easy availability, we aimed to investigate whether routine blood parameters provide useful clues for phenotypic classification and disease prognosis.

Methods

We analyzed a large inpatient cohort of 836 ALS patients who underwent deep phenotyping with evaluation of the clinical and neurophysiological burden of upper (UMN) and lower (LMN) motor neuron signs. Disability and progression rate were measured through the revised ALS Functional Rating Scale (ALSFRS-R) and its changes during time. Cox regression analysis was performed to assess survival associations.

Results

Creatinine significantly correlated with LMN damage (r = 0.38), active (

SUBMITTER: Gentile F 

PROVIDER: S-EPMC10827966 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature