Quantitative and Qualitative Assessment of Urinary Activity of ¹⁸F-Flotufolastat-PET/CT in Patients with Prostate Cancer: a Post Hoc Analysis of the LIGHTHOUSE and SPOTLIGHT Studies.

ABSTRACT:

Purpose

To evaluate the impact of urinary activity on interpretation of ¹⁸F-flotufolastat (¹⁸F-rhPSMA-7.3) PET/CT, we conducted a post hoc qualitative and quantitative analysis of scans acquired in two phase 3 studies of ¹⁸F-flotufolastat.

Procedures

Newly diagnosed or recurrent prostate cancer patients enrolled in LIGHTHOUSE (NCT04186819) or SPOTLIGHT (NCT04186845), respectively, underwent PET/CT 50-70 min after intravenous administration of 296 MBq ¹⁸F-flotufolastat. For the present analysis, 718 ¹⁸F-flotufolastat scans (352 from LIGHTHOUSE and 366 from SPOTLIGHT) were re-evaluated by three board-certified nuclear medicine physicians. Reader 1 performed a quantitative assessment (SUV_max and SUV_mean

SUBMITTER: Kuo PH 

PROVIDER: S-EPMC10827967 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature