Microbiota signatures associated with invasive Candida albicans infection in the gastrointestinal tract of immunodeficient mice.

ABSTRACT: Candida albicans is a commensal microorganism in the human gut but occasionally causes invasive C. albicans infection (ICA), especially in immunocompromised individuals. Early initiation of antifungal therapy is associated with reduced mortality of ICA, but rapid diagnosis remains a challenge. The ICA-associated changes in the gut microbiota can be used as diagnostic and therapeutic targets but have been poorly investigated. In this study, we utilized an immunodeficient Rag2γc (Rag2-/-il2γc-/-) mouse model to investigate the gut microbiota alterations caused by C. albicans throughout its cycle, from its introduction into the gastrointestinal tract to invasion, in the absence of antibiotics. We observed a significant increase in the abundance of Firmicu

SUBMITTER: Yan JY 

PROVIDER: S-EPMC10828038 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature