The Balance Between the Therapeutic Efficacy and Safety of [¹⁷⁷Lu]Lu-NeoB in a Preclinical Prostate Cancer Model.

ABSTRACT:

Purpose

Radiolabeled NeoB is a promising gastrin-releasing peptide receptor (GRPR)-targeting radiopharmaceutical for theranostics of GRPR-expressing malignancies, e.g., prostate cancer (PCa). The aim of this study was to evaluate the effect of different doses of [¹⁷⁷Lu]Lu-NeoB on the balance between therapeutic efficacy and safety in a preclinical PCa model.

Procedures

To determine the efficacy of [¹⁷⁷Lu]Lu-NeoB, PC-3 xenografted mice received 3 sham injections (control group) or 3 injections of 30 MBq/300 pmol, 40 MBq/400 pmol, or 60 MBq/600 pmol [¹⁷⁷Lu]Lu-NeoB (groups 1, 2, and 3, respectively) 1 week apart. To quantify tumor uptake, single-photon emission computed tomography/computed tomography (SPECT/CT) imaging was performed 4 h after th

SUBMITTER: Verhoeven M 

PROVIDER: S-EPMC10828073 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature