HIF-1A as a prognostic biomarker related to invasion, migration and immunosuppression of cervical cancer.

ABSTRACT:

Background

The incidence of cervical cancer ranks second among malignant tumors in women, exerting a significant impact on their quality of life and overall well-being. The hypoxic microenvironment plays a pivotal role in the initiation and progression of tumorigenesis. The present study aims to investigate the fundamental genes and pathways associated with the hypoxia-inducible factor (HIF-1A) in cervical cancer, aiming to identify potential downstream targets for diagnostic and therapeutic purposes.

Methods

We obtained dataset GSE63514 from the Comprehensive Gene Expression Database (GEO). The dataset comprised of 24 patients in the normal group and 28 patients in the tumor group. Gene set difference analysis (GSVA) and gene set enrichment analysis (GSEA) were used to iden

SUBMITTER: Li Z 

PROVIDER: S-EPMC10828096 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature