Serum factors mediate changes in mitochondrial bioenergetics associated with diet and exercise interventions.

ABSTRACT: Mitochondrial improvements resulting from behavioral interventions, such as diet and exercise, are systemic and apparent across multiple tissues. Here, we test the hypothesis that factors present in serum, and therefore circulating throughout the body, can mediate changes in mitochondrial function in response to intervention. To investigate this, we used stored serum from a clinical trial comparing resistance training (RT) and RT plus caloric restriction (RT + CR) to examine effects of blood borne circulating factors on myoblasts in vitro. We report that exposure to dilute serum is sufficient to mediate bioenergetic benefits of these interventions. Additionally, serum-mediated bioenergetic changes can differentiate between interventions, recapitulate sex differences in bioenergetic respons

SUBMITTER: Gonzalez-Armenta JL 

PROVIDER: S-EPMC10828137 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature