Metabolomic characterization of vigor to frailty among community-dwelling older Black and White men and women.

ABSTRACT: Older women and Black individuals are more likely to experience frailty. A metabolomic characterization of frailty may help inform more effective interventions aimed at improving health, reducing disparities, and preventing frailty with aging. We sought to identify metabolites and pathways associated with vigor to frailty and determine whether associations differed by sex and/or race among n = 2189 older Black and White men and women from the Health, Aging, and Body Composition (Health ABC) study. Fasting plasma metabolites were measured using liquid chromatography-mass spectrometry. Vigor to frailty was based on weight change, physical activity, gait speed, grip strength, and usual energy. We used linear regression of a single metabolite on vigor to frailty, adjusting for age, sex, race,

SUBMITTER: Marron MM 

PROVIDER: S-EPMC10828147 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature