Hyperbaric oxygen alleviates selective domains of cognitive and motor deficits in female 5xFAD mice.

ABSTRACT: Treatment of Alzheimer's disease (AD) has been limited to managing of symptoms or anti-amyloid therapy with limited results and uncertainty. Seeking out new therapies that can reverse the effects of this devastating disease is important. Hyperbaric oxygen (HBO) therapy could be such a candidate as it has been shown to improve brain function in certain neurological conditions. Furthermore, the role sex plays in the vulnerability/resilience to AD remains equivocal. An understanding of what makes one sex more vulnerable to AD could unveil new pathways for therapy development. In this study, we investigated the effects of HBO on cognitive, motor, and affective function in a mouse model of AD (5xFAD) and assessed protein oxidation in peripheral tissues as a safety indicator. The motor and cogni

SUBMITTER: Mensah-Kane P 

PROVIDER: S-EPMC10828284 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature