Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism.

ABSTRACT: Understanding the mechanisms of geroprotective interventions is central to aging research. We compare four prominent interventions: senolysis, caloric restriction, in vivo partial reprogramming, and heterochronic parabiosis. Using published mice transcriptomic data, we juxtapose these interventions against normal aging. We find a gene expression program common to all four interventions, in which inflammation is reduced and several metabolic processes, especially fatty acid metabolism, are increased. Normal aging exhibits the inverse of this signature across multiple organs and tissues. A similar inverse signature arises in three chronic inflammation disease models in a non-aging context, suggesting that the shift in metabolism occurs downstream of inflammation. Chronic inflammation is also

SUBMITTER: Landsberger T 

PROVIDER: S-EPMC10828297 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature