Dorsal and ventral fronto-amygdala networks underlie risky decision-making in age-related cognitive decline.

ABSTRACT: Older adults often have difficulty in making decisions under uncertainty, increasing the risk of financial exploitation. However, it is still under investigation about the extent to which cognitive decline influences risky decision-making and the underlying neural correlates. We hypothesized that the individual differences of risk-taking behavior depend on cognitive integrity, in which the dorsal and ventral fronto-amygdala connectivity would play dissociable roles. In the current study, thirty-six young and 51 older adults were tested with the Iowa gambling task combing resting-state and task-related functional magnetic resonance imaging. The results showed significant changes in behaviors and the fronto-amygdala network in older adults relative to young adults. More importantly, age-effe

SUBMITTER: Ren P 

PROVIDER: S-EPMC10828304 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature