Plasma neurofilament light chain in relation to 10-year change in cognition and neuroimaging markers: a population-based study.

ABSTRACT: Neurofilament light chain (NfL) is a promising biomarker for risk stratification and disease monitoring of dementia, but its utility in the preclinical disease stage remains uncertain. We determined the association of plasma NfL with (change in) neuroimaging markers and cognition in the population-based Rotterdam Study, using linear and logistic regression and mixed-effects models. Plasma NfL levels were measured using the Simoa NF-light™ assay in 4705 dementia-free participants (mean age 71.9 years, 57% women), who underwent cognitive assessment and brain MRI with repeated assessments over a 10-year follow-up period. Higher plasma NfL was associated with worse cognitive performance at baseline (g-factor: β =  - 0.12 (- 0.15; - 0.09), p < 0.001), and accelerated cognitive decline during fo

SUBMITTER: van Arendonk J 

PROVIDER: S-EPMC10828339 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature