Developing a Tool for Differentiation Between Bacterial and Viral Respiratory Infections Using Myxovirus Resistance Protein A and C-Reactive Protein.

ABSTRACT:

Introduction

The aim was to assess the performance of a blood assay combining measurements of MxA (myxovirus resistance protein A) and CRP (C-reactive protein) to differentiate viral from bacterial respiratory infections.

Methods

In a prospective study, MxA and CRP were measured in the blood by the AFIAS panel in adults admitted with respiratory infection. Patients were split into discovery and validation cohorts. Final diagnosis was adjudicated by a panel of experts. Microbiology-confirmed cases comprised the discovery cohort, and infections adjudicated as highly probable viral or bacterial comprised the validation cohort.

Results

A total of 537 patients were analyzed: 136 patients were adjudicated with definitive viral infections and 131 patients with definitive bac

SUBMITTER: Iliopoulou K 

PROVIDER: S-EPMC10828347 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature