Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice.

ABSTRACT: Cognitive dysfunction following radiotherapy (RT) is one of the most common complications associated with RT delivered to the brain, but the precise mechanisms behind this dysfunction are not well understood, and to date, there are no preventative measures or effective treatments. To improve patient outcomes, a better understanding of the effects of radiation on the brain's functional systems is required. Functional magnetic resonance imaging (fMRI) has shown promise in this regard, however, compared to neural activity, hemodynamic measures of brain function are slow and indirect. Understanding how RT acutely and chronically affects functional brain organization requires more direct examination of temporally evolving neural dynamics as they relate to cerebral hemodynamics for bridging with

SUBMITTER: Seitzman BA 

PROVIDER: S-EPMC10828348 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature