Age-related decrease in inter-subject similarity of cortical morphology and task and resting-state functional connectivity.

ABSTRACT: "All old people are the same" is an unfortunate characterization of the perceived homogeneity in the older age group. This study attempts to debunk this myth in the context of the structural and functional brain. Within older relative to younger age groups, individuals are hypothesized to be more dissimilar to their similar-aged peers-thus demonstrating an age-related divergence. This study analyzed functional connectivity (FC) during multiple fMRI paradigms (2 rest + 5 tasks) and cortical thickness (CT) data from two lifespan datasets (N_total = 1161). On average, between-subject FC/CT correlations became weaker in the older age groups. Further analyses ruled out the possibility that more rapid age-related changes in older brains have increased the dissimilarity in these older a

SUBMITTER: Yu J 

PROVIDER: S-EPMC10828367 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature