Reduction in metabolic noise reveals rejuvenation following transient severe caloric restriction.

ABSTRACT: Among land vertebrates, the laying hen stands out due to its great reproductive efficiency: producing an egg daily all year long. This production rate makes the laying hen a special model animal to study the general process of reproduction and aging. One unique aspect of hens is their ability to undergo reproductive plasticity and to rejuvenate their reproductive tract during molting, a standard industrial feed restriction protocol for transiently pausing reproduction, followed by improved laying efficiency almost to peak production. Here we use longitudinal metabolomics, immunology, and physiological assays to show that molting promotes reproduction, compresses morbidity, and restores youthfulness when applied to old hens. We identified circulating metabolic biomarkers that quantitatively

SUBMITTER: Levkovich G 

PROVIDER: S-EPMC10828374 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature