Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma.

ABSTRACT: While changes in RNA splicing have been extensively studied in hepatocellular carcinoma (HCC), no studies have systematically investigated changes in RNA splicing during earlier liver disease. Mouse studies have shown that disruption of RNA splicing can trigger liver disease and we have shown that the splicing factor SRSF3 is decreased in the diseased human liver, so we profiled RNA splicing in liver samples from twenty-nine individuals with no-history of liver disease or varying degrees of non-alcoholic fatty liver disease (NAFLD). We compared our results with three publicly available transcriptome datasets that we re-analyzed for splicing events (SEs). We found many changes in SEs occurred during early liver disease, with fewer events occurring with the onset of inflammation and fibrosis

SUBMITTER: Webster NJG 

PROVIDER: S-EPMC10828381 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature