LAFEM: A Scoring Model to Evaluate Functional Landscape of Lysine Acetylome.

ABSTRACT: Protein lysine acetylation is a critical post-translational modification involved in a wide range of biological processes. To date, about 20,000 acetylation sites of Homo sapiens were identified through mass spectrometry-based proteomic technology, but more than 95% of them have unclear functional annotations because of the lack of existing prioritization strategy to assess the functional importance of the acetylation sites on large scale. Hence, we established a lysine acetylation functional evaluating model (LAFEM) by considering eight critical features surrounding lysine acetylation site to high-throughput estimate the functional importance of given acetylation sites. This was achieved by selecting one of the random forest models with the best performance in 10-fold cross-validation on

SUBMITTER: Liang JZ 

PROVIDER: S-EPMC10828473 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature