Deciphering the molecular functionality of Cdc45 in replisomal complex.

ABSTRACT: The members of DHH superfamily have been reported with diverse substrate spectrum and play pivotal roles in replication, repair, and RNA metabolism. This family comprises phosphatases, phosphoesterase and bifunctional enzymes having nanoRNase and phosphatase activities. Cell cycle factor Cdc45, a member of this superfamily, is crucial for movement of the replication fork during DNA replication and an important component of the replisome. The specific protein-protein interactions of Cdc45 with other factors along with helicase moderate the faithful DNA replication process. However, the exact biochemical functions of this factor are still unknown and need further investigation. Here, we studied the biochemical roles of Cdc45 and its molecular interactions within the replisomal complex. The a

SUBMITTER: Radhakrishnan A 

PROVIDER: S-EPMC10828582 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature