Tozasertib activates anti-tumor immunity through decreasing regulatory T cells in melanoma.

ABSTRACT: Although immune checkpoint therapy has significantly improved the prognosis of patients with melanoma, urgent attention still needs to be paid to the low patient response rates and the challenges of precisely identifying patients before treatment. Therefore, it is crucial to investigate novel immunosuppressive mechanisms and targets in the tumor microenvironment in order to reverse tumor immune escape. In this study, we found that the cell cycle checkpoint Aurora kinase B (AURKB) suppressed the anti-tumor immune response, and its inhibitor, Tozasertib, effectively activated T lymphocyte cytokine release in vitro and anti-tumor immunity in vivo. Tozasertib significantly inhibited melanoma xenograft tumor growth by decreasing the number of inhibitory CD4⁺ T_reg cells in

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10828585 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature