Correlation between symptoms and cognitive function changes in patients with primary insomnia and pathways in gut microbiota.

ABSTRACT:

Background

Primary insomnia (PI) refers to syndromes of difficulty falling asleep, poor sleep quality, early awakening, and difficulty falling asleep after waking up. Although there have been numerous studies, the specific etiology and pathogenesis of PI are still misunderstanding. In recent years, the gut microbiota has been proved to be involved in the metabolism of many mental disorders. But the specific mechanisms of its involvement in PI have not been fully elucidated. This study aims to explore the relationship between the gut microbiota and the symptoms, cognitive function changes in PI.

Methods

In this study, the gut microbiota of PI patients and healthy controls was profiled by performing stool 16s rRNA gene sequencing. The co-occurrence network was constructed by u

SUBMITTER: Nie L 

PROVIDER: S-EPMC10828595 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature