Molecular recognition of Escherichia coli R1-type core lipooligosaccharide by DC-SIGN.

ABSTRACT: Due to their ability to recognize carbohydrate structures, lectins emerged as potential receptors for bacterial lipopolysaccharides (LPS). Despite growing interest in investigating the association between host receptor lectins and exogenous glycan ligands, the molecular mechanisms underlying bacterial recognition by human lectins are still not fully understood. We contributed to fill this gap by unveiling the molecular basis of the interaction between the lipooligosaccharide of Escherichia coli and the dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin (DC-SIGN). Specifically, a combination of different techniques, including fluorescence microscopy, surface plasmon resonance, NMR spectroscopy, and computational studies, demonstrated that DC-SIGN

SUBMITTER: Nieto-Fabregat F 

PROVIDER: S-EPMC10828809 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature