Treatment Outcome of Severe Respiratory Type B Tularemia Using Fluoroquinolones.

ABSTRACT:

Background

Fluoroquinolones lack approval for treatment of tularemia but have been used extensively for milder illness. Here, we evaluated fluoroquinolones for severe illness.

Methods

In an observational study, we identified case-patients with respiratory tularemia from July to November 2010 in Jämtland County, Sweden. We defined severe tularemia by hospitalization for >24 hours and severe bacteremic tularemia by Francisella tularensis subsp. holarctica growth in blood or pleural fluid. Clinical data and drug dosing were retrieved from electronic medical records. Chest images were reexamined. We used Kaplan-Meier curves to evaluate time to defervescence and hospital discharge.

Results

Among 67 case-patients (median age, 66 years; 81% males) 30-day mortality was 1.5% (

SUBMITTER: Widerstrom M 

PROVIDER: S-EPMC10828930 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature